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KMID : 0043320100330071059
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Archives of Pharmacal Research
2010 Volume.33 No. 7 p.1059 ~ p.1063
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Interaction of supraspinally administered interferon-alpha with opioid system in the production of antinociception
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Lee Jin-Koo
Park Soo-Hyun
Sim Yun-Beom
Jung Jun-Sub
Suh Hong-Won
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Abstract
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We examined the antinociceptive effect of intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered of interferon-alpha (IFN-α) using the tail-flick analgesic test in mice. IFN-α administered i.c.v. but not i.t. showed an antinociceptive effect in a dose-dependent manner (0.05?5 μg). To examine the possible interaction with brain opioid system, IFN-α was cotreated with either β-endorphin or morphine. Combined i.c.v. treatment of IFN-α (0.5 μg) with β-endorphin (0.125 μg) caused a synergistic antinociceptive effect. And also, the synergistic interaction maintained at least for 60 min after the co-treatment of IFN-α and β-endorphin. However, the combined treatment of i.t. IFN-α with i.c.v. β-endorphin showed neither an additive nor a synergistic antinociceptive profile. The i.c.v. co-treatment of IFN-α with morphine (0.2 μg) showed an additive antinociceptive effect only. The i.t. administered IFN-α did not show any additive antinociceptive effect when morphine was administered i.c.v. simultaneously. Taken together, our results suggest that supraspinally co-administered IFN-α and β-endorphin may produce antinociception synergistically via interaction of IFN-α with supraspinal β-endorphin sensitive opioid receptors.
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KEYWORD
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Interferon-alpha, Beta-endorphin, Morphine, Tail-flick test, Synergistic, interaction, Antinociception
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